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Title: Chaperonin-mediated Protein Folding
Originating Office: PAO
Speaker: Horwich, Arthur L
Issue Date: 18-Sep-2012
Event Date: 18-Sep-2012
Group/Series/Folder: Record Group 3.8 - Office of University Development and Public Affairs
Series 6 - Audio-visual Materials
Location: 3.8:6 box 6.3.5
Notes: Shaw Prize Lecture in Life Science and Medicine.
Title from opening screen: Shaw Prize Lecture in Life Science and Medicine 2012.
Abstract: Prof Arthur L. Horwich introduced the protein folding studies over the past several decades, a screen in yeast for genes involved with the import of proteins into mitochondria. This process had been shown to require unfolding of precursor proteins during translocation across the membranes, thus necessitating refolding in the innermost matrix compartment. He also analyzed the structural and functional studies of bacterial homologue GroE. The study has now offered a mechanistic understanding of how the protein folding leading to Cystic Fibrosis, Alzheimer's disease and Huntington's disease.
Arthur L Horwich was born in Chicago, USA in 1951. He currently holds the position of Professor of Genetics at the Yale University School of Medicine and Investigator of the Howard Hughes Medical Institute. He received his undergraduate and medical training at Brown University from 1969 to 1973. After a period of postgraduate clinical training in pediatrics at Yale, Horwich devoted himself to a basic science career as a postdoctoral fellow at the Salk Institute (1978 - 1981) and then back at Yale (1981 - 1984). He has remained on the Yale faculty since that time. In addition to numerous prizes, including the Lasker Award in Basic Medical Science, which he shared with Franz-Ulrich Hartl in 2011, Horwich was elected to the United States National Academy of Sciences in 2003.
Duration: 67 min.
Appears in Series:3.8:6 - Audio-visual Materials
Videos for Public -- Distinguished Lectures