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Title: Leader Cells in Collective Migration
Originating Office: IAS
Speaker: Silberzan, Pascal
Issue Date: 10-Dec-2009
Event Date: 10-Dec-2009
Group/Series/Folder: Record Group 8.15 - Institute for Advanced Study
Series 3 - Audio-visual Materials
Location: 8.15:3 box 1.4
Notes: Institute for Advanced Study Workshop: Evolution: Foundations, Fundamentals, and Disease. Session 4: The role of evolution in biological disease: Cancer and cell dynamics.
Abstract: We generate model wounds by using an original microfabrication‐based technique based on a microstencil that masks portions of the surface during the growth of a monolayer. Removing the stencil at the confluence of epithelial MDCK cells does not damage the border cells but triggers the collective motility of the epithelium, while cells maintain strong adhesions between them. By using hydrodynamics derived techniques such as Particle Image Velocimetry (PIV), based on the correlations between successive images, we observe that this collective motility involves long-range coordinated displacements of large groups of cells well within the monolayer. This observation contradicts the commonly accepted view in which only the border cells are affected.
Duration: 50 min.
Appears in Series:8.15:3 - Audio-visual Materials
Videos for Public -- Distinguished Lectures