Files in This Item:
| File | Format | ||
|---|---|---|---|
| b1112281.mp4 | Streaming Video | View/Open |
| Title: | Evolution in Cancer |
| Originating Office: | IAS |
| Speaker: | Maley, Carlo |
| Issue Date: | 9-Dec-2009 |
| Event Date: | 9-Dec-2009 |
| Group/Series/Folder: | Record Group 8.15 - Institute for Advanced Study Series 3 - Audio-visual Materials |
| Location: | 8.15:3 box 1.4 |
| Notes: | Institute for Advanced Study Workshop: Evolution: Foundations, Fundamentals, and Disease. Session 4: The role of evolution in biological disease: Cancer and cell dynamics. Abstract: Our current theory of carcinogenesis is that mutant clones arise through genetic or epigenetic instability, and if they have a reproductive or survival advantage over other cells in the tumor, within their microenvironment, they will expand in the tumor in a selective sweep. Thus, we believe carcinogenesis is characterized by a series of selective sweeps. However, virtually all data on that process to date is cross‐sectional, with observations of genetic diversity and large clonal expansions within neoplasms at a single time point. Duration: 51 min. |
| Appears in Series: | 8.15:3 - Audio-visual Materials Videos for Public -- Distinguished Lectures |