Files in This Item:
File Format
b1112281.mp4Streaming VideoView/Open
Title: Evolution in Cancer
Originating Office: IAS
Speaker: Maley, Carlo
Issue Date: 9-Dec-2009
Event Date: 9-Dec-2009
Group/Series/Folder: Record Group 8.15 - Institute for Advanced Study
Series 3 - Audio-visual Materials
Location: 8.15:3 box 1.4
Notes: Institute for Advanced Study Workshop: Evolution: Foundations, Fundamentals, and Disease. Session 4: The role of evolution in biological disease: Cancer and cell dynamics.
Abstract: Our current theory of carcinogenesis is that mutant clones arise through genetic or epigenetic instability, and if they have a reproductive or survival advantage over other cells in the tumor, within their microenvironment, they will expand in the tumor in a selective sweep. Thus, we believe carcinogenesis is characterized by a series of selective sweeps. However, virtually all data on that process to date is cross‐sectional, with observations of genetic diversity and large clonal expansions within neoplasms at a single time point.
Duration: 51 min.
Appears in Series:8.15:3 - Audio-visual Materials
Videos for Public -- Distinguished Lectures