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IAS-2009-Landweber-epigenetic-oxytricha.mp4Streaming VideoView/Open
Title: RNA-mediated Epigenetic Inheritance in Oxytricha
Originating Office: IAS
Speaker: Landweber, Laura
Issue Date: 9-Dec-2009
Event Date: 9-Dec-2009
Group/Series/Folder: Record Group 8.15 - Institute for Advanced Study
Series 3 - Audio-visual Materials
Location: 8.15:3 box 1.4
Notes: Institute for Advanced Study Workshop: Evolution: Foundations, Fundamentals, and Disease. Session 2: Moving beyond classic darwinian evolution.
Abstract: RNA, normally thought of as a conduit in gene expression, displays a novel mode of action inciliates, where RNA molecules provide both an organizing role in DNA rearrangements and a template that can transmit somatic substitutions to the next generation (Nowacki et al. 2008. Nature 451, 153‐158). The opportunity for RNA-guided DNA repair is profound in Oxytricha, which destroys 95% of its germline genome through a process that severely fragments its chromosomes and then sorts and reorders the hundreds of thousands of tiny pieces remaining. Information for reordering comes from transiently‐expressed maternal non‐coding RNAs. A complete RNA cache of the maternal somatic genome may be available at a specific stage during development to provide a template for DNA rearrangement and to transmit heritable information.
Duration: 63 min.
Appears in Series:8.15:3 - Audio-visual Materials
Videos for Public -- Distinguished Lectures