Files in This Item:
File Format
b1109651.mp4Streaming VideoView/Open
Title: Rapid Evolution of Antibiotic Resistance
Originating Office: IAS
Speaker: Hwa, Terence
Issue Date: 8-Dec-2009
Event Date: 8-Dec-2009
Group/Series/Folder: Record Group 8.15 - Institute for Advanced Study
Series 3 - Audio-visual Materials
Location: 8.15:3 box 1.4
Notes: Institute for Advanced Study Workshop: Evolution: Foundations, Fundamentals, and Disease. Session 2: Moving beyond classic darwinian evolution.
Abstract: Rapid emergence of drug resistance is one of the biggest problem facing treatment of disease ranging from bacterial infection to cancer. Recently, we found that sublethal levels of translation‐inhibiting antibiotics resulted in attenuation of constitutively expressed genes in bacteria, a generic effect which can be understood in terms of simple bacterial growth laws. This effect suggests a novel growth-mediated positive feedback mechanism by which weak expression of antibiotic resistance may be amplified without the need of any specific regulation. A distinct signature of such positive feedback is an abrupt change in bacterial growth over small changes in drug levels in the vicinity of a critical drug level.
Duration: 55 min.
Appears in Series:8.15:3 - Audio-visual Materials
Videos for Public -- Distinguished Lectures